Book Review: Regenesis by George M. Church and Edward Regis

Regenesis: How Synthetic Biology Will Reinvent Nature and Ourselves is an exhilarating journey that re-shapes our understanding of life itself. The book is written by George M. Church and Edward Regis. It was first published in 2012. The renowned geneticist and science writer collaborated to present an all-encompassing exploration of synthetic biology. And highlighting its thrilling potentialities along with obvious challenges. In this remarkable masterpiece, they have woven following three distinct levels of exploration.

Read More

Minimal Organisms Shape Evolution: The Power of Simplicity

Genomes come in various levels of complexity. Of course, it also depends on the number of genes an organism possesses. A genome is set of genetic material or DNA (deoxyribonucleic acid) present in a living entity. It contains all the instructions necessary for an organism’s development, functioning, and reproduction. Not all living entities have equal number of genomes. Some bacteria, for instance, have very few genes, while plant and animal genomes can have tens of thousands.

Read More

RNA-Guided Endonucleases in Eukaryotes: Genetic Tools found in Nature

An international team of researchers has identified a programmable RNA-guided system in eukaryotes. Eukaryotes encompass plants, animals, fungi, and protists. The newly discovered system is based on a protein called Fanzor. It uses RNA as a guide to precisely target DNA. The researchers demonstrated that Fanzor proteins can be reprogrammed to edit the genome of human cells. Compared to CRISPR/Cas systems, the Fanzor system is more compact and has the potential to be delivered more easily to cells and tissues as therapeutics.

Read More

Biodegradable Gel shows promise for Cartilage Regeneration: Biomaterial Engineering

One of the biggest challenges that still haunts tissue engineering and regenerative medicine is, how to mimic the properties of articular cartilage in synthetic materials. Articular cartilage possesses a unique combination of stiffness and toughness. These features allow the connective tissues to withstand the mechanical stresses and strains experienced during joint movement.

Read More

Targeting Folate Receptors in Gliomas: A New Way to Detect Brain Tumors

Recent research conducted by Maxwell Miner from the University of Turku in Finland, working at the Turku PET Centre, sheds light on the potential of folate receptors as a valuable tool in the field of brain tumor imaging and treatment. Folate-based radiopharmaceuticals are a type of medical imaging agent that combines folate – a form of vitamin B9 – with a radioactive substance.

Read More

DNA Damage Repaired through Antioxidant Enzymes: Genetic Restoration

At the fundamental level, function of human cell is to convert nutrients into energy and useful products that sustain life. In the process, these cells give out certain waste products that otherwise cause harm to the inner environment. For instance, reactive oxygen species (ROS) molecule is one of the natural byproducts of cellular metabolism. ROS are highly reactive molecules that contain oxygen atoms with unpaired electrons.

Read More

Distinct Activation Patterns of Projection Neurons: Cortical Dynamics

Cerebral cortex is the outer layer of cerebrum, that is the largest part of the brain. All kinds of higher-level processes such as language, memory, and decision-making are performed in this region. The complex, densely packed structure is saturated with various types of neurons. It is extremely difficult to image its neuronal dynamics with the necessary spatial and temporal resolution. So far, fMRI (functional magnetic resonance imaging) technique is widely used for studying brain activity. However, when it comes down to examine neural circuitry at the point of a single…

Read More

Book Review: The Immortal Life of Henrietta Lacks by Rebecca Skloot

The Immortal Life of Henrietta Lacks is a beautiful book written by Rebecca Skloot in 2010. It is about a poor African American woman who came down with a rare cervical cancer in 1950s. After giving birth to her fourth child, Henrietta grew suspicious of a lump in her cervix. To clarify things, she went straight to Johns Hopkins Hospital. The doctor took a biopsy by extracting sample cells for examination. Although she couldn’t survive, after a few sessions of x-ray therapy and radium treatment. She died at the age…

Read More

Neuro-Stack to records Single Neuron Activity: Brain Mechanisms of Movement

New technologies have revolutionized many fields, including medicine and neuroscience. Advances in engineering, materials science, and computer technology have enabled the development of increasingly sophisticated devices for recording and analysing biological signals, such as brain activity, with unprecedented precision and accuracy. For instance, electroencephalography (EEG) is a non-invasive technique that measures electrical activity in the brain using electrodes placed on the scalp. With the advancement in electronics and computing the EEG signals can now be recorded with greater precision and resolution.

Read More

Hydrogels Promote Neuronal Tissue Growth: Brain Healing

Degeneration of brain cells could be a natural aging process. However, destruction or deterioration of brain cells could occur due to a wide range of internal as well as external factors. In general, brain damage refers to significant, undiscriminating trauma-induced damage. Science has tremendously advanced when it comes to health care and disease control. There are new and radical developments in the field of neurology alone. One such progress is brain tissue reconstruction.

Read More

Exon Junction Complex controls mRNA: RNA Methylation

Our gene expression is regulated by RNA methylation. Same process also affects various cellular processes like differentiation and development. Lately, University of Chicago researchers, led by Chuan He, have uncovered new insights into how genes work by solving a long-standing mystery related to RNA methylation. Researchers in Chuan He’s lab have been studying RNA methylation and its potential impact on human health for over a decade.

Read More

Gas Entrapping Materials to Mitigate Tumor Hypoxia: GeM Technology

Cancer treatments such as radiotherapy and chemotherapy have been shown to be less effective when exposed to a hypoxic environment. In fact, low oxygen levels in tumors can also escalate disease progression. Hyperbaric oxygen therapy and microbubble infusion are the two techniques through which oxygen levels in tumors can be increased to improve treatment outcomes.

Read More

Compact Cas7-11 Enzyme for RNA Editing: CRISPR-Cas System

The CRISPR CAS9 system famously known as genetic scissors was discovered by Emmanuelle Charpentier and Jennifer Doudna in 2012. And since then, the new tool has been studied extensively across global academia. Initial studies of the genome editing tool altered only the DNA. However, lately the CAS system is also studied for editing RNA. What is CRISPR-CAS system? CRISPR-CAS system is an adaptive immune system of bacteria, which protects it from invaders. Also, it defends the bacterial host from renewed infection as it memorizes previous infections. DNA has the fingerprint.…

Read More